Endocrine Abstracts

Introduction: Despite recent developments in biochemical, radiological and molecular techniques, a preoperative diagnosis of parathyroid carcinoma (PC) remains a difficult task. The main challenge of all studies in this area is a small number of cases based on retrospective data. The search for new blood biomarkers associated with PC could be important for early diagnosis and prognosis. Dysregulated microRNA (miRNA) levels are involved in tumorigenesis and may serve as diagnos...

Introduction: Multiple endocrine neoplasia type 4 (MEN4) is a rare disorder, caused by inactivating mutations in CDKN1B gene that encodes p27kip1 cyclin-dependent kinase inhibitor. To date nine different germline CDKN1B mutations have been described in patients with clinical features of multiple endocrine neoplasia type 1 (MEN1) negative for MEN1 mutations (MEN1 phenocopies).Case report: We present a female 54 y.o. w...

Heterogeneity of diabetes mellitus (DM) determines difficulties in the diabetes type verification and further treatment. With this regard, in 2019 WHO published a new classification of DM with categories: “hybrid types of diabetes” and “unclassified diabetes” intended for use in clinical practice.Aim: To investigate the heterogeneity and clinical features of DM in young adult patients with an unspecified type of diabetes.<p cl...

Background: MiRNAs are small non-coding RNAs, which regulate biological and pathological processes, including organogenesis, apoptosis, cell proliferation and differentiation. Considering the complexity of the parathyroid cancer (PC) diagnosis, discovering of new markers of the disease, which may help to evaluate the prognosis before surgical treatment, becomes an important problem. We studied the differences in miRNA expression profile in the blood serum between patients with...